The Hughes Fire near Castaic, California, has burned over 5,000 acres, prompting evacuations and school closures.

A rare Particularly Dangerous Situation warning has been issued for Southern California as a powerful and potentially damaging Santa Ana wind event​ is expected.

"A strong Santa Ana Wind event is expected to develop Monday and last through at least Tuesday," the National Weather Service said.

The Los Angeles haven’t spread in nearly a week, but the return of the Santa Ana winds to full strength could cause problems.

The Santa Ana winds fanning wildfires that have killed at least 25 people in Southern California and destroyed more than 10,000 houses, businesses and other structures in Greater Los Angeles are flaring up again.

The Santa Anas are expected to be most powerful Monday night into Tuesday. Fire services across the region say they are ready.

A wind-driven wildfire charred dozens of acres in the sparsely developed northeastern reaches of San Diego County, damaging structures and forcing pre-dawn evacuations before crews could gain the upper hand on the flames Wednesday.

Santa Ana winds occur when air flows west from a region of high pressure over the dry Great Basin to lower pressure off the California coast, According to Accuweather. As that cool interior air flows over and through mountain passes, it accelerates, sinks and compresses.

Firefighters gained more ground Thursday on a fast-moving brushfire that erupted north of Los Angeles the day before and within hours exploded to thousands of acres amid high winds, officials said.

LOS ANGELES – Santa Ana winds continued to gust across Southern California Thursday, driving new fires that have forced evacuations in Los Angeles and San Diego counties. Firefighters battling a fire in the Sepulveda Basin that has scorched 45 acres in Brentwood have the blaze 60 percent contained Thursday.

Rain expected in L.A. this weekend has raised concerns about mud flows, but the National Weather Service says the rains will not be significant enough to create dramatic flows capable of extinguishing the fires. Dr. Daniel Swain, a UCLA climate scientist, added that coming rain could be meaningless.